Protective effects of β-eudesmol against septic liver injury via inhibition of NF-κB signaling

Purpose: To investigate the role of β-eudesmol in septic liver injury mice.Methods: Mice were intraperitoneally injected with 50 or 100 mg/kg β-eudesmol, and then subjected to cecal ligation puncture for establishment a model 2 h later. Haematoxylin eosin staining was used evaluate histopathological changes tissues. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) enzyme-linked immunosorbent assay (ELISA) employed determine damage, while inflammation oxidative stress evaluated by ELISA.Results: Liver tissues mice showed infiltration inflammatory cells, vacuolar degeneration obscure nucleus. However, treatment ameliorated (p < 0.01). Moreover, also reduced hepatocyte apoptosis, decreased levels biomarkers damage. The up-regulation TNF-α, IL-1β, IL-6 significantly down-regulated 0.01), but increased superoxide dismutase (SOD) glutathione (GSH) malondialdehyde (MDA) myeloperoxidase (MPO) order protect against sepsis. In addition, attenuated punctureinduced p-p65 0.01).Conclusion: β-Eudesmol exerts anti-inflammatory anti-oxidant effects inactivating NF-κB signaling, thus may be useful as potential agent management